Feeling abandoned and alienated by her faith, a shattered and despondent Vanessa seeks the help of Dr. Seward, an American therapist who has an unconventional way of treatment. Meanwhile, now a prisoner under the watchful eye of Scotland Yard Inspector Rusk, Ethan Chandler is on a train speeding through the desert of the American West. Halfway around the world, in Zanzibar, Sir Malcolm is confronted by a mysterious Native American man named Kaetenay who shares a deep connection with Ethan. Back in London, Dr. Frankenstein seeks out his old friend Dr. Jekyll. With all of her friends scattered around the world facing their own demons, Vanessa is left alone to battle a new evil that has emerged from the shadows.

Ethan gets help from Hecate. Evil forces track Vanessa's every move.

Vanessa is confronted by a familiar, who reveals a clue to her past.

Vanessa convinces Dr. Seward to use hypnosis to take her back in time.

Hecate and Ethan struggle to survive in the harsh desert wasteland.

Vanessa turns to an old friend for help, who introduces her to a new ally.

Kaetenay has a vision of impending doom. Vanessa learns an awful truth.

Dr. Seward uncovers a secret. Ethan goes in search of Dr. Frankenstein.

Season finale.