Superstar genetic engineers Clive (Adrien Brody) and Elsa (Sarah Polley) specialize in splicing DNA from different animals to create incredible new hybrid that could revolutionize science and medicine. But when the pharmaceutical company that funds their research forbids it, they secretively take their experiment underground - risking their careers to push the boundaries of science and serve their own curiosity and ambition. The result is Dren, who exceeds their wildest dreams - and threatens to become their worst nightmare.